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2/12/14Scientist May Have Found a Way to Reverse Myelin Damage in Those With MSDr. Vittorio Gallo, director at Center for Neuroscience Research at Children’s National Medical System, and fellow researchers were able to identify a molecule, Endothelin-1 (ET-1), as what inhibits the repair of myelin and believe they can find a way to ‘target’ this protein to stimulate the repairing of the sheathe.
Dr. Gallo and laboratory members directed their attention to and are currently moving on with the next step: “They are currently analyzing ET-receptor B knock-out mutants to determine which ET receptor subtype is involved in the biological effects observed.
Finding ways to repair the myelin that MS destroys is a fairly new path, in that it has been in only the last few years that findings have been coming out; scientists and researchers have taken in trying to stop the progression
Dr. Gallo said, “We demonstrate that ET-1 drastically reduces the rate of remyelination. This creates a new drug target in the treatment of MS [as] ET-1 is “potentially a therapeutic target to promote lesion repair in deymyelinated tissue.”
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